(8-3) is coming off one of its biggest wins in recent memory, a 20-17 victory over No. 5 Stanford
They wrap up their regular season in two weeks hosting crosstown rival UCLA.
In the meantime? The Trojans must travel to Colorado to take on the 4-6 Buffs.
It's a prototypical trap game.
Still high off a big win, already looking ahead to the Bruins.
Can Colorado pull off an upset no one saw coming?
USC interim head coach Ed Orgeron says "it's a challenge" making sure his players are focused on Saturday's game and Saturday's game, alone.
"I trust our guys," he said after Tuesday's practice. "I trust our process, I trust that they respect what we're doing and they understand we have a lot of things to play for and Colorado is an important game."
The Pac-12 cellar-dweller a season ago, the Buffs managed their first Pac-12 win of the season -- a 41-24 win over California on Saturday -- though they're still tied for last in the Pac-12 South with Utah.
"We treat all our opponents the same," Orgeron insisted. "We will work as hard as we can just like we would for anybody else."
"It doesn't matter who it is," quarterback Cody Kessler explained after practice, "We have to stay focused and a lot of teams do mess up stuff like that, they come off a big win and have a let up and take the next week lightly. We have not done that at all."
USC has played Colorado seven times in its history, twice since the Buffs joined the Pac-12. The Trojans have never lost to Colorado.
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USC travels to Colorado this weekend to take on the Buffaloes. The Trojans are coming off a 20-17 upset victory over No. 5 Stanford and have a Nov. 30 meeting with crosstown rival UCLA -- is it possible for Colorado to catch USC still celebrating a big win and also looking past them toward the Bruins?